NOTE: This test is ONLY AVAILABLE TO AUSTRALIAN RESIDENTS.
Mould illness or Chronic Inflammatory Response Syndrome (CIRS) is a common but poorly recognized condition because of many debilitating (but not obvious) symptoms including chronic fatigue, generalised pain, headaches, depression, sinusitis, rashes and anxiety. Many of these conditions are caused by exposure to the interior environment of water damaged buildings (WDBs). Chronic fatigue syndrome is often misdiagnosed and can be associated with mould exposure, as studies show a significant percentage of patients with chronic fatigue syndrome test positive for mycotoxins. These organisms grow on household surfaces that have high cellulose content, such as wood, fibreboard, gypsum board, paper, dust and lint. The most common types of mould that are found indoors include: Cladosporium, Penicillium, Alternaria, Aspergillus and Stachybotrys (black mould).
Mould Biotoxins are shed into the environment of WDBs and are acquired into the body via foods, water, air, or insect bites. They cause inflammatory responses via influencing/affecting signalling pathways in the body, releasing inflammatory cytokines. They aggravate existing lung diseases, and can cause inflammation of the lungs. Chronic illness can arise from persistent exposure to mould toxins, especially in individuals with certain genetic predispositions who struggle to clear these toxins, resulting in widespread inflammation.
In the general population, biotoxins are removed from the body via the bloodstream through the liver or alternatively broken down by the body’s immune system and excreted out of the body.
However, in patients with a compromised immune system (either genetically or environmentally), biotoxins can remain within the body for lengthy periods of time and exacerbate the above conditions. This susceptible group seem to be unable to clear mould toxins easily and efficiently. Their symptoms though are often vague, since toxins can affect any body organ. For CIRS patients, specific diets like the No-Amylose Diet and blood tests measuring biomarkers such as leptin and VEGF are crucial for understanding and managing their health outcomes.
Since mould toxins cause inflammation through activation of cytokines, there are a number of lab tests which can show the effects of inflammation.
What is Mould Illness?
Mould illness, also known as Chronic Inflammatory Response Syndrome (CIRS), is a condition that occurs when the body’s immune system overreacts to mould exposure. This overreaction can lead to a myriad of symptoms, including chronic fatigue, muscle pain, joint pain, and respiratory issues. Mould illness is often triggered by exposure to mould in water-damaged buildings, where species like Aspergillus, Penicillium, and Stachybotrys thrive. When these moulds release spores, mycotoxins, and biotoxins into the air, they can be inhaled or come into contact with the skin, prompting an immune response that can become chronic and debilitating.
What the test looks at: Immune System
C3a
C4a
TGFB-1
Melanocyte Stimulating Hormone (MSH)
Vascular Endothelial Growth Factor (VEGF): VEGF is a protein that stimulates blood vessel formation. In the context of Chronic Inflammatory Response Syndrome (CIRS), low levels of VEGF may result from elevated TGF-b1, leading to symptoms like fatigue and muscle cramps. It is also relevant in other conditions like asthma and certain cancers.
Leptin: Leptin is a hormone involved in regulating energy balance. In CIRS patients, abnormal leptin levels can indicate issues with inflammation and metabolism.
Understanding individual test results within the normal range is crucial, as these ranges can vary based on factors such as age, sex, and body mass index.
About the Moulds/Biotoxins Comprehensive Test for Chronic Inflammatory Response Syndrome
The moulds/biotoxins comprehensive test is a simple blood test that can be done right near your home or office. The test is looking for all of the above mentioned makers. The test includes:
An authorized blood specimen order form that you take to your local accredited pathology for collection of your blood (Find a pathology near you here).
A blood specimen test kit for the pathology to use to collect your blood sample
Complete instructions for taking the test for you and the pathology
The test also includes mycotoxin testing, which measures the levels of mould toxins in the blood, providing direct evidence of exposure.
Organic Acids Testing (OAT) is a diagnostic tool used to assess various health markers related to gastrointestinal activity, nutrient status, and metabolic function. This test can indicate dysbiosis and offer personalized health recommendations based on the results, highlighting its significance in understanding overall health.
Test results are sent to one of our professional health practitioners within 12 – 14 business days for evaluation. Our practitioners contact you with the results and recommendations on any findings via email, mail or phone. The test also includes support services related to health conditions caused by toxic mould exposure, emphasizing the significance of biomarkers in diagnosing Chronic Inflammatory Response Syndrome (CIRS) linked to toxic mould.
Common Symptoms of Mould/Biotoxins Toxicity
Mould/biotoxins toxicity can manifest through a wide range of symptoms, making it a challenging condition to diagnose. Common symptoms include:
Chronic fatigue
Muscle pain
Joint pain
Respiratory problems
Skin problems
Gastrointestinal issues
Neurological disturbances
Mood changes
Respiratory issues
These symptoms are often exacerbated in individuals with a compromised immune system, making it difficult for their bodies to effectively eliminate the mould toxins.
Testing for Mould Illness
Testing for mould illness involves a comprehensive approach, utilizing various types of tests to detect the presence of mould toxins and assess immune system function. Common tests include:
Blood tests for mycotoxins and biotoxins
Urine tests for mycotoxins and biotoxins
Stool tests to evaluate gut health
Skin prick tests to identify mould exposure
These tests help health practitioners pinpoint the specific mould toxins affecting the patient and determine the extent of immune system dysfunction.
Diagnosing Mould Exposure
Diagnosing mould exposure can be a complex process, as the symptoms often mimic those of other conditions. However, several tests and methods can help pinpoint mould exposure and its effects on the body.
One of the most common diagnostic tools is blood tests. These tests can measure the levels of mould toxins in the blood and assess the body’s immune response to mould exposure. Key blood tests include:
Mycotoxin Testing: This test measures the levels of mould toxins present in the blood, providing direct evidence of exposure.
Immune System Testing: This test evaluates the body’s immune response to mould exposure, identifying any abnormalities or heightened activity.
Inflammatory Cytokine Testing: This test measures the levels of inflammatory cytokines in the blood, which can indicate an ongoing inflammatory response due to mould exposure.
Another valuable diagnostic method is Organic Acids Testing (OAT). OAT is a urine test that measures the levels of organic acids, which are byproducts of mould exposure. Elevated levels of these acids can signal mould exposure and help guide treatment.
In addition to these tests, health practitioners may use other diagnostic tools, such as:
Physical Examination: A thorough physical exam can reveal symptoms like skin rashes or respiratory issues that may be linked to mould exposure.
Medical History: Reviewing a patient’s medical history can uncover previous mould exposure or sensitivities that might contribute to current symptoms.
Environmental Testing: Testing the home or workplace for mould can identify potential sources of exposure, aiding in diagnosis and prevention.
By combining these diagnostic methods, health practitioners can accurately diagnose mould exposure and develop effective treatment plans tailored to each patient’s needs.
The Role of Vascular Endothelial Growth Factor (VEGF) in Mould Exposure
Vascular Endothelial Growth Factor (VEGF) is a critical protein involved in the body’s response to mould exposure. VEGF regulates blood vessel growth and permeability, playing a significant role in the inflammatory response.
When the body encounters mould toxins, it releases VEGF to manage the resulting inflammation. However, this can lead to increased blood vessel permeability, allowing mould toxins to enter the bloodstream and exacerbate inflammation. Elevated VEGF levels are often found in individuals with mould exposure and are closely linked to Chronic Inflammatory Response Syndrome (CIRS). This condition is characterized by chronic inflammation and a range of symptoms, including chronic fatigue, muscle cramps, and respiratory issues.
VEGF is not only relevant in mould exposure but also in other conditions like chronic fatigue syndrome and fibromyalgia. In these conditions, elevated VEGF levels contribute to chronic inflammation, highlighting the protein’s role in various inflammatory diseases.
Health practitioners may use VEGF testing as part of a comprehensive diagnostic approach to mould exposure. By measuring VEGF levels, they can gain insights into the extent of inflammation and tailor treatment plans accordingly.
In managing mould exposure, dietary adjustments such as adopting a gluten-free diet can help reduce inflammation and improve symptoms. Additionally, maintaining a healthy gut microbiome is crucial, as the GI tract plays a vital role in immune system function and overall health. By addressing both dietary and environmental factors, patients can achieve better health outcomes and manage the effects of mould exposure more effectively.
Treatment for Mould Illness
Treating mould illness requires a multifaceted approach, combining medication, dietary adjustments, and lifestyle changes. Common treatments include:
Toxin binders like cholestyramine or Welchol to help remove mould toxins from the body
Dietary changes, such as adopting a gluten-free diet, to reduce inflammation and support healing
Lifestyle modifications, including avoiding further mould exposure and managing stress, to alleviate symptoms and promote recovery
By addressing both the physical and environmental factors, patients can achieve significant improvements in their health.
How to Complete the Test
Completing the test for mould illness involves several straightforward steps:
Collect a blood, urine, or stool sample, depending on the specific test being conducted.
Send the sample to a designated laboratory for analysis.
Receive the test results and discuss them with a healthcare practitioner.
Develop a personalized treatment plan based on the test results and individual health needs.
Following the instructions provided by the laboratory and healthcare practitioner is crucial to ensure accurate test results and effective treatment. This comprehensive approach helps in identifying the root cause of symptoms and tailoring a treatment plan that addresses the unique needs of each patient.
Common Symptoms of Mould Illness / Biotoxins Toxicity
Fatigue
Weakness
Muscle aches and cramps (low levels of VEGF may contribute to this)
Headaches
Sensitivity to bright light
Unusual pains
Fibromyalgia
Abdominal pains, nausea, diarrhea
Chronic sinus congestion
Coughing, chest pain, shortness of breath
Joint pain with morning stiffness
Cognitive impairment
Skin sensitivity to light touch
Numbness and tingling
Sensitivity to electrical shocks
Metallic taste in the mouth
Excessive thirst
Menstrual problems
Dizziness and or disequilibrium
Appetite swings and weight gain
Anxiety and or depression, mood swings
Night sweats
Frequent urination
Body temperature dysregulation
Impotence
Odd ticks and spasms and seizure like events
Neurological disturbances
The GI tract plays a crucial role in fungal infections and dysbiosis, impacting overall health through the metabolism of organic acids and microbial overgrowth.
Also see the related test here.
Low levels of vasoactive intestinal polypeptide (VIP) in CIRS can lead to inflammation and immune dysregulation.
